1312 Heterogeneities in proteomic profiles among African American and East African patients with atopic dermatitis

While the atopic dermatitis/AD phenotype has been classically defined as a systemic Th2/22 skewed inflammatory disease, heterogeneities between different ancestries and races, such those Asians Asian Americans, have shown that both environmental genetic factors contribute to progression severity of disease which can give rise differential treatment responses. However, proteomic characterization African American/AA, East African, European American/EA patients with AD are currently unavailable we aim bridge this gap. We performed analysis on blood samples from 56 (10 Tanzanian, 17AA, 29EA) 40 ethnicity-matched controls (9 11AA, 20EA) by using OLINK immune inflammation target panel (96 proteins). Across our panel, several differentially expressed proteins/DEPs were found AA Africans. Tanzanian showed upregulations in Th2 markers (IL6, IL10RA p<.05) presenting higher pruritus-related (IL7, IL10RA, OPG, OSM; p<.05). Tanzanians significant upregulation innate immunity IL8, TGFB1; p<.05), T cell activation (TNFRSF-9, SLAMF1, MMP1; along Th1 (CD40, CXCL10, CXCL9; Additionally, also Th17 not seen AA. Our findings corroborate expand current knowledge profiles. Africans commonly treated one homogenous population context AD, protein marker profiles may indicate diverging potentiates novel, targeted, more individualized therapeutics.